NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on October 12, 2025, at 8:30 AM EDT. This week's NFL picks are based on the current trends and statistics.
Bold Predictions for Week 6
Last week's NFL bold predictions went 2-1, resulting in a gain of +1.17 units overall. Since the start of Week 3, the picks in this story are up 2.16 units.
This Week's Picks
Fading the Colts offense may not be the wisest choice, but there's a case for doing so. Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if they maintain this pace all season.
Indianapolis is currently averaging 3.39 points per drive.
Author's summary: NFL Week 6 picks and predictions.
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